The treatment of pericardial effusion depends on its cause and severity. If it is due to an underlying infection, antibiotics or antiviral medications may be prescribed. In some cases, anti-inflammatory drugs can help reduce inflammation and fluid accumulation. If the effusion is large and causing significant symptoms such as shortness of breath or chest pain, a procedure called pericardiocentesis may be performed to drain the fluid. In severe cases, surgery may be necessary to remove the pericardium or repair any underlying heart problems. ????