If your hands itch after handling yams, here are some solutions. Rinse your hands thoroughly with cool water as soon as possible. This can help remove any residual yam sap. You can then soak your hands in vinegar or rubbing alcohol for a few minutes. These substances can help neutralize the irritating substances on your skin. Applying a cold compress to your itchy hands can also provide relief. If the itching is severe, you can take an antihistamine medication as directed by a doctor. Avoid scratching your hands as it can make the itching worse and may cause skin damage.